By Jose M. Palacios, Angel Pazos, Daniel Hoyer (auth.), Giuseppe Di Giovanni, Ennio Esposito, Vincenzo Di Matteo (eds.)
Research of 5-HT2c receptors stretches again twenty-five years, and whereas a lot of it's been efficient, the earlier decade of study has been notable when it comes to either quantity produced and insights won. it really is hardly ever incredible that 5-HT2c receptor examine has grown so fruitful, on condition that it's a famous primary serotonin receptor subtype broadly expressed in the imperative and the peripheral worried procedure and is believed to play an enormous function within the rules of various behaviors. It has extra been proven via experimental and medical commentary that it might signify a potential healing aim for the advance of gear for quite a number relevant worried approach problems. The time, as a result, is greater than applicable to provide the 1st ever evaluation of the examine of 5-HT2c receptors. a part of the preferred and critical sequence, “The Receptors,” The 5-HT2c Receptor presents a radical replace of the sensible prestige of the 5-HT2c receptor. It covers the molecular, mobile, anatomical, biochemical and behavioral features of this receptor to be able to spotlight its special regulatory houses and the rising useful importance of constitutive task and RNA-editing in vivo. additionally, the e-book investigates the receptors’ healing power in quite a number diversified illnesses, handled separately in separate chapters, together with melancholy, drug abuse, schizophrenia, consuming issues, Parkinson’s ailment, Prader-Willi Syndrome, Alzheimer’s illness and epilepsy. whereas no longer exhaustive, this article is a crucial software in figuring out the prior and encouraging the way forward for interdisciplinary study at the 5-HT2c receptor.
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Extra info for 5-HT2C Receptors in the Pathophysiology of CNS Disease
According to the authors this colocalization could provide an anatomical basis for earlier observations that alterations in serotonergic input can lead to changes in the levels of striatal neuropeptides (Kondo et al. 1993). 2 5-HT2C Receptors and Serotonergic or GABAergic Neurons The cellular localization of 5-HT2C receptor mRNA in relation to serotonergic and GABAergic neurons has been studied in the anterior raphe nuclei of the rat (Serrats et al. 2005). In the dorsal and median raphe nuclei, 5-HT2C receptor mRNA is not detected in serotonergic cells identified as those expressing serotonin (5-HT) transporter mRNA.
However, several other diverse functional in vitro models (biochemical assays or tissue preparations) have been employed such as phosphoinositide hydrolysis in rat or pig choroid plexus (5-HT2C), phosphoinositide hydrolysis in rat cortex (5-HT2A), effect on human platelet aggregation (5-HT2A), contraction of rat jugular vein (5-HT2A), contraction of the isolated rat tail artery (5-HT2A), and contraction of isolated rat stomach fundus muscle strips (5-HT2B). Yet, another complicating factor is that the 5-HT2C receptor undergoes post-transcriptional mRNA editing.
This model has been proposed to explain the increases in the frequency of inhibitory postsynaptic currents (IPSCs) induced by 5-HT and the 5-HT2A/2C agonist DOI [1-(2,5)-dimethoxy-4-iodophenyl-2-aminopropane] when applied to rat brain slices containing the dorsal raphe. The localization of the 5-HT2C receptor in GABAergic cells has been also described in other brain areas. Immunohistochemical analyses on the 5-HT2C receptor reveals that this receptor is mainly expressed in deep layers of the rat medial prefrontal cortex (Liu et al.
5-HT2C Receptors in the Pathophysiology of CNS Disease by Jose M. Palacios, Angel Pazos, Daniel Hoyer (auth.), Giuseppe Di Giovanni, Ennio Esposito, Vincenzo Di Matteo (eds.)